0000132090 00000 n Active ingredients Added ingredients Products used in the manufacture of the vaccine Growing the active ingredients Further information The information on this page is based on the best information that we can find from the available literature. 0000005016 00000 n JZD| According to the information that AstraZeneca and the University of Oxford presented to the United Kingdom's vaccine regulatory agency, this vaccine contains: The vaccine does not include any human or animal products, thimerosal, gelatin, or formaldehyde. endobj AstraZeneca is a member of Covax, a global initiative aiming to distribute two billion vaccine doses to 92 low- and middle-income countries at no more than $3 a dose. Read all of this leaflet carefully before the vaccine is given because it contains important information for you. 0000000016 00000 n The COVID-19 vaccines currently approved for use in the UK are: Moderna (Spikevax) Pfizer/BioNTech (Comirnaty) Novavax (Nuvaxovid) AstraZeneca (Oxford) (not available) Janssen (Johnson & Johnson) (not available) Valneva (Valneva) (not available) Which vaccine will I get? or call 1-800-FDA-1088 or call AstraZeneca at 1-800-236-9933. endstream endobj 76 0 obj <> stream 54 0 obj 0000004587 00000 n Younger patients may be more likely to experience anaphylaxis. A court in Belgium . The benefits of booster vaccination are recognized following increasing evidence of waning vaccine effectiveness against mild and asymptomatic SARS-CoV-2 infection over time. Download PDF. Store in a refrigerator (2C to 8C). It does not have a marketing authorisation, but this temporary authorisation grants permission for the medicine to be used for active immunisation of individuals aged 18 years and older for the prevention of coronavirus disease 2019 (COVID-19). Some cases were life-threatening or had a fatal outcome. If side effects such as pain and/or fever are troublesome, medicines containing paracetamol can be taken. During use it can be stored from 2C to 25C. When COVID-19 Vaccine AstraZeneca is given for the first injection, the second injection to complete the vaccination course should also be with COVID-19 Vaccine AstraZeneca. Once it is approved for human research, there are three phases that take place before the vaccine can be considered for approval for public use. How to store COVID-19 Vaccine AstraZeneca 6. No data are currently available in individuals with a weakened immune system or who are taking chronic treatment that suppresses or prevents immune responses. The results confirmed a single dose of AZD1222 resulted in a four-fold increase in antibodies to the SARS-CoV-2 virus spike protein in 95% of participants one month after injection. Other reactions reported in this group include muscle aches (60%), malaise (61%), chills (56%), and feeling feverish (51%). People with a history of severe allergic reaction to any component of the vaccine should not take it. _:);~6`Tgx_A/`d`G,~#V?]|j~^9jfWu?g8uN~Tg'~^'G%|S>#Z{,gcOgg"Q27v}IyaM|"6ocj 4.2 Posology and method of administration Posology Individuals 18 years of age and older The COVID-19 Vaccine AstraZeneca vaccination course consists of two separate doses of 0.5 ml each. The Global Advisory Committee on Vaccine Safety, a group of experts that provides independent and authoritative guidance to the WHO on the topic of safe vaccine use, receives and assesses reports of suspected safety events of potentially international Component. Statement of the WHO Global Advisory Committee on Vaccine Safety (GACVS) COVID-19 subcommittee on safety signals related to the AstraZeneca COVID-19 vaccine, Interim statement of the COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety on AstraZeneca COVID-19 vaccine, The Janssen Ad26.COV2.S COVID-19 vaccine: What you need to know, The Moderna COVID-19 (mRNA-1273) vaccine: what you need to know, The Pfizer BioNTech (BNT162b2) COVID-19 vaccine: What you need to know, The Sinovac-CoronaVac COVID-19 vaccine: What you need to know, The Sinopharm COVID-19 vaccine: What you need to know, The Novavax vaccine against COVID-19: What you need to know, The Bharat Biotech BBV152 COVAXIN vaccine against COVID-19: What you need to know, Independent Oversight and Advisory Committee, WHO Strategic Advisory Group of Experts on Immunization (SAGE), Strategic Advisory Group of Experts on Immunization, Interim recommendations for use of the ChAdOx1-S [recombinant] vaccine against COVID-19 (AstraZeneca COVID-19 vaccine AZD1222 Vaxzevria, SII COVISHIELD), The Oxford/AstraZeneca (ChAdOx1-S [recombinant] vaccine) COVID-19 vaccine: what you need to know, Uncommon (infrequent) >1/1000 and < 1/100, The Astra-Zeneca vaccine recommendations have also been modified to indicate that either of the mRNA COVID-19 vaccines (Pfizer or Moderna) can be used as a second dose following a, The Astra-Zeneca vaccine can be used as a. This means that it is essentially 'sodium-free'.. The recommended dosage is two doses given intramuscularly (0.5ml each) with an interval of 8 to 12 weeks. /Root 55 0 R endstream endobj 75 0 obj <> stream 0000025064 00000 n Health information in your inbox, every other week. It has been adjusted to work as a delivery system for the vaccine. <]/Prev 553136>> For instance, preservatives prevent the vaccine from going bad or being spoiled. 870 0 obj <>stream Vaccines are widely used to prevent infections, and most traditional vaccines that target viruses are made from dead or attenuated live viruses (viruses that have been altered so they are not harmful) to help people develop immunity without becoming ill. Oops! %%EOF Information about the Moderna coronavirus vaccine, including a full list of ingredients and side effects, is available: Information on the Moderna COVID-19 vaccine. This remarkable achievement is much-needed good news as COVID-19 cases are currently at their highest daily levels globally.2 . 10 dose multidose vial (5 ml) with rubber stopper and aluminium overseal in a pack of 10 vials. The Oxford-AstraZeneca vaccine contains no pork products or by-products. Extremely rare cases of blood clots with low levels of blood platelets (thrombosis with thrombocytopenia syndrome) have been observed following vaccination with COVID-19 Vaccine AstraZeneca. Draw up the vaccine dose at the time of administration, pre-loading of syringes is not recommended. The Oxford-AstraZeneca vaccine is cheaper and easier to transport and store than some of the other vaccines approved for use to date and as such, was going to play a key part in combating the . Providing this 2021 Jan 9;397(10269):72-74. doi: 10.1016/S0140-6736(20)32623-4. b AV Q4 8=0 ) This product contains genetically modified organisms (GMOs). Nanolipid components of the Moderna vaccine include: (SM-102, 1,2-dimyristoyl-rac-glycero3- This publication is licensed under the terms of the Open Government Licence v3.0 except where otherwise stated. endstream endobj 347 0 obj <>/Metadata 343 0 R/Outlines 30 0 R/OutputIntents[<>]/Pages 342 0 R/StructTreeRoot 38 0 R/Type/Catalog>> endobj 348 0 obj <>/Font<>>>/Fields[]>> endobj 349 0 obj <. This means that it is essentially sodium-free. these events. 0000007190 00000 n COVID-19 Vaccine AstraZeneca stimulates the bodys natural defences (immune system). 0000000016 00000 n The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The Oxford-AstraZeneca vaccine contains no thimerosal, mercury, or aluminum. dwS(V"2G %[CA+|}e9;(al-U c9.3T@k w *Recombinant, replication-deficient chimpanzee adenovirus vector encoding the SARS-CoV-2 Spike glycoprotein. You may need to read it again. Results from a large clinical trial in the United States and South America indicate that AstraZeneca's COVID-19 vaccine, AZD1222, is well-tolerated and protects against symptomatic COVID-19 disease, including severe disease or hospitalization. 0000007733 00000 n If you get any side effects, talk to your doctor, pharmacist or nurse. %PDF-1.7 % 0000015344 00000 n Vaccines are generally very safe and their study involves a rigorous process. 0000003540 00000 n If you experience any of the following from around 4 days after vaccination you should seek medical advice urgently: Tell your doctor, pharmacist or nurse if you experienced a blood clot occurring at the same time as low levels of platelets after receiving a previous dose of the vaccine. If you are concerned about a side-effect it can be reported directly via the Coronavirus Yellow Card reporting site or search for MHRA Yellow Card in the Google Play or Apple App Store and include the vaccine brand and batch/Lot number if available. ]0[ The Astra-Zeneca vaccine can be offered to people who have had COVID-19 in the past. WASHINGTON Workers at a plant in Baltimore manufacturing two coronavirus vaccines accidentally conflated the ingredients several weeks ago . The expiry date refers to the last day of that month. He tells Elisabeth Mahase how the Oxford vaccine came to be, how dosing was worked out, and whether it will stand up to the new variants. None of the ingredients in this vaccine can cause COVID-19. Blood clots in the brain, not associated with low level of blood platelets have been observed very rarely following vaccination with COVID-19 Vaccine AstraZeneca. It is a proven, safe and relatively old approach. Additional Information If you have questions, visit the website or call the telephone number provided However, it is not confirmed whether these events were due to the vaccine. 0000018147 00000 n 0000003715 00000 n Here are the ingredients for the three vaccines currently available in Australia: Vaxzevria, made by AstraZeneca, Comirnaty, made by Pfizer, and Spikevax, made by Moderna. 0000082759 00000 n Any unused vaccine or waste material should be disposed of in accordance with local requirements. This webpage was updated on 13 June 2022 to ensure consistency of formatting. COVID-19 Vaccine (ChAdOx1 S [recombinant]). 0000002358 00000 n When these blood clots do occur, they may be in unusual or atypical locations (e.g. The need for, and timing of, booster doses for children aged 5-11 years has not yet been determined. Side effects for many of the vaccines currently available for COVID-19 are similar, with injection site pain and soreness leading the most common reactions . 0000006393 00000 n endobj It will take only 2 minutes to fill in. Dont worry we wont send you spam or share your email address with anyone. Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned. A new investigational treatment for COVID-19: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Some affected patients had a previous diagnosis of CLS. 0000054470 00000 n Preservatives in this vaccine are disodium edetate dihydrate and ethanol. This means that a COVID-19 vaccine cannot make you sick with COVID-19. Article number: 33474. These ingredients range from forms of salt that help preserve the vaccine to water that dilutes it into the right concentration. hbbd``b` $HpXAv DL) The vaccine is not recommended for persons younger than 18 years of age pending the results of further studies. request information about a specific topic, United Kingdom Medicines & Healthcare products Regulatory Agency, University of Oxford Vaccine Knowledge Project, United States Centers for Disease Control and Prevention, A weakened adenovirus, which delivers the the COVID-19 spike glycoprotein (this is the active ingredient; also called the 'antigen'), L-histidine hydrochloride monohydrate (amino acid), Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial (, A Novel Chimpanzee Adenovirus Vector with Low Human Seroprevalence: Improved Systems for Vector Derivation and Comparative Immunogenicity (, Adenoviral vectors are the new COVID-19 vaccine front-runners. 0000003743 00000 n 3.What if I am taking, have recently taken or might take other medicinesor 0000103790 00000 n Spills should be disinfected using agents with activity against adenovirus. endstream endobj 549 0 obj <. 2.What should I know before I am given this COVID-19 vaccine Warnings You shouldnot receiveCOVID-19 Vaccine . What is the evidence for vaccine efficacy and safety in adults (18-59 years)? Vaccine AstraZeneca and those who received control. 0000107012 00000 n LqIai8O=,*EM~|>0: NiV|+'#M(FYQc`uic+)Gy1Q(:'4~0:,9Dbdf&. This included some severe cases with blood clots in different or unusual locations and excessive clotting or bleeding throughout the body. 569 0 obj <>/Filter/FlateDecode/ID[<422DFA914F61AD45909E39C193482A39>]/Index[548 34]/Info 547 0 R/Length 105/Prev 177378/Root 549 0 R/Size 582/Type/XRef/W[1 3 1]>>stream %%EOF In this vaccine ,polysorbate 80 works to separate the listed ingredient of water from other oil-based ingredients. 0000102287 00000 n 0000003094 00000 n 0000102152 00000 n The AstraZeneca vaccine is safe and effective at protecting people from the extremely serious risks of COVID-19, including death, hospitalization and severe disease. If you have a previous diagnosis of capillary leak syndrome (a condition causing fluid leakage from small blood vessels). Neutralising activity against SARS-CoV-2 (as assessed by the MNA80 assay) was seen in 91% of participants one month after vaccination and in 100% of participants who received a second dose. If you feel unwell after vaccination, do not drive or use machines. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This webpage was updated on 5 January 2022 to update the latest guidance and ensure consistency of information and formatting. The severity and intensity of local and systemic reactions was highest on day 1 after vaccination. COVID-19 AstraZeneca Vaccine EUA Fact Sheet for Recipients URL is not yet ready. Overall, among the participants who received COVID-19 Vaccine AstraZeneca, 90.3% were aged 18 to 64 years and 9.7% were 65 years of age or older. Last updated by Judith Stewart, BPharm on Feb 15, 2021.. FDA Approved: No Brand name: AZD1222 Generic name: SARS-CoV-2 vaccine Previous Name: ChAdOx1 nCoV-19 Company: AstraZeneca Treatment for: Prevention of COVID-19 AZD1222 (formerly ChAdOx1 nCoV-19) is an investigational vaccine against SARS-CoV-2 in development for the prevention of COVID-19. 410 0 obj <>stream 0000097826 00000 n (Centers for Disease Control and Prevention). }wfydUj_mr\]]s=']O_Od>MdD.PHTpo If your fever is high and lasts longer than two or three days, or you have other persistent symptoms, this might not be due to side effects of the vaccine and you should follow appropriate advice according to your symptoms. Moderna COVID-19 vaccine. 803 0 obj <>/Filter/FlateDecode/ID[<2F70D35E7B8A59458B52A8ED8203A71C><24F7C9D4F005C249BEA4CA3B57A534AF>]/Index[779 189]/Info 778 0 R/Length 129/Prev 229930/Root 780 0 R/Size 968/Type/XRef/W[1 3 1]>>stream SAGE accepts two heterologous doses of WHO EUL COVID-19 vaccines as a complete primary series. 0000001732 00000 n 0000082376 00000 n >> up to 16 weeks can be considered. Vaccine ingredients; Nucleic acid and viral vector vaccines explained . Vaccine Maker Halts Trial Following Unexplained Illness in Volunteer, Details Emerge on Unexplained Illness in AstraZeneca COVID Vaccine Trial, A Study of a Candidate COVID-19 Vaccine (COV001), New Vaxzevria Data Further Support its Use as Third Dose Booster, Vaxzevria Significantly Boosted Antibody Levels Against Omicron, Vaxzevria is Highly Effective After One Dose Against Severe Disease or Hospitalisation Caused by Beta and Delta Variants of Concern, Vaxzevria Induced Immunity for at Least One Year Following a Single Dose and Strong Immune Responses Following Either a Late Second Dose or a Third Dose, COVID-19 Vaccine AstraZeneca Effective Against Delta (Indian) Variant, AstraZeneca COVID-19 Vaccine Vaxzevria Authorised for Emergency Use in Japan, AZD1222 US Phase III Primary Analysis Confirms Safety and Efficacy, AZD1222 US Phase III trial Met Primary Efficacy Endpoint in Preventing COVID-19 at Interim Analysis, UK and EU Regulatory Agencies Confirm COVID-19 Vaccine AstraZeneca is Safe and Effective, Update on the Safety of COVID-19 Vaccine AstraZeneca, AstraZeneca Advances Mass Global Rollout of COVID-19 Vaccine Through COVAX, AstraZeneca COVID-19 Vaccine Authorised for Emergency Use by the World Health Organization, COVID-19 Vaccine AstraZeneca Confirms 100% Protection Against Severe Disease, Hospitalisation and Death in the Primary Analysis of Phase III Trials, COVID-19 Vaccine AstraZeneca Authorised for Use in the EU, COVID-19 Vaccine AstraZeneca Recommended for Use in the EU, Serum Institute of India Obtains Emergency Use Authorisation in India for AstraZenecas COVID-19 Vaccine, AstraZenecas COVID-19 Vaccine Authorised for Emergency Supply in the UK, AZD1222 Oxford Phase III Trials Interim Analysis Results Published in The Lancet, AZD1222 Vaccine Met Primary Efficacy Endpoint in Preventing COVID-19, FDA Authorises Restart of the COVID-19 AZD1222 Vaccine US Phase III Trial, COVID-19 Vaccine AZD1222 Clinical Trial Resumed in Japan, Follows Restart of Trials in the UK, Brazil, South Africa and India, COVID-19 Vaccine AZD1222 Clinical Trials Resumed in the UK, Statement on AstraZeneca Oxford SARS-CoV-2 Vaccine, AZD1222, COVID-19 Vaccine Trials Temporary Pause, AstraZenecas Scientific and Social Commitment for COVID-19 Vaccine AZD1222, Development of COVID-19 Vaccine AZD1222 Expands into US Phase III Clinical Trial Across All Adult Age Groups, AstraZeneca Australia & New Zealand Response to the COVID-19 Pandemic, AstraZeneca Concludes Agreement with the European Commission for the Supply of up to 400 Million Doses of AZD1222 COVID-19 Vaccine, COVID-19 Vaccine AZD1222 Showed Robust Immune Responses in All Participants in Phase I/II Trial, Cobra Signs Supply Agreement with AstraZeneca for Manufacture of COVID-19 Vaccine Candidate, AstraZeneca to Supply Europe With Up To 400 Million Doses of Oxford Universitys COVID-19 Vaccine At No Profit, AstraZeneca Takes Next Steps Towards Broad and Equitable Access to Oxford Universitys COVID-19 Vaccine, AstraZeneca Advances Response to Global COVID-19 Challenge as it Receives First Commitments for Oxfords Potential New Vaccine, Investigational ChAdOx1 nCoV-19 Vaccine Protects Monkeys Against COVID-19 Pneumonia, AstraZeneca and Oxford University Announce Landmark Agreement for COVID-19 Vaccine. United Kingdom, MedImmune Pharma B.V., Nijmegen M Ms CZHto ) [recombinant]) [COVID-19 Vaccine AstraZeneca]with other vaccines have not been evaluated. 18 June 2021. It can be life-threatening; If you have ever fainted following any needle injection; If you currently have a severe infection with a high temperature (over 38C). 0000014217 00000 n Something went wrong while submitting the form. . Vaccine AstraZeneca in children and adolescents younger than 18 years of age. Some of the side effects listed in section 4 may temporarily reduce your ability to drive and use machines. Tell your doctor, pharmacist or nurse if you are taking, have recently taken or might take, any other medicines or vaccines. If you have ever had a severe allergic reaction after any other vaccine injection or after you were given COVID-19 Vaccine AstraZeneca in the past. It is not yet known how long you will be protected for. After vaccination, the surface spike protein is produced, priming the immune system to attack the virus if it later infects the body, protecting it against COVID-19. WHO does not recommend delaying pregnancy or terminating pregnancy because of vaccination. Contact your doctor or healthcare professional immediately or go to the nearest hospital emergency room right away if you have an allergic reaction. Andrew Pollard has been leading the Oxford vaccine clinical trials in the UK, Brazil, and South Africa. Treatment for: Prevention of COVID-19. In the meantime, we must maintain and strengthen public health and social measures that work: masking, physical distancing, handwashing, respiratory and cough hygiene, avoiding crowds, and ensuring good ventilation. Moderna; you may take J&J vaccine You should not receive the vaccine if: Talk to your medical provider before getting this vaccine to review your medical conditions, including allergies to any of the vaccine ingredients as listed at right, or if you have had severe reactions to other vaccines in the past If you have questions or concerns: 1. 581 0 obj <>stream All 28 developed different types of clots, or thromboses, five to 16 days after vaccination, and all had made antibodies against platelets. Safety data sheet. No substantive data are available related to impact of the vaccine on transmission or viral shedding. 0000001096 00000 n Published March 31, 2021 Updated Aug. 1, 2021. 0000103016 00000 n The Janssen COVID-19 Vaccine includes the following ingredients: recombinant, replication-incompetent adenovirus type 26 expressing the SARS -CoV-2 spike protein, citric acid As new data become available, WHO will update recommendations accordingly. This Oxford-AstraZeneca vaccine uses the ChAdOx1 technology, which has been developed and optimised by the Jenner Institute over the last 10 years. Contents of the pack and other information 1. Company: AstraZeneca The human protein impurities - mostly heat shock and cell scaffold proteins - come from the human kidney cell line used to generate the chimp adenovirus. Talk to the healthcare provider if you have questions. 0000002960 00000 n Further to this, SAGE recommends that severe and moderately immunocompromised persons should be offered an additional dose of vaccine. 2020 has been a difficult year for all, but has seen 58 vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) be developed and in clinical trials,1 with some vaccines reportedly having more than 90% efficacy against COVID-19 in clinical trials. An email has been sent to you to confirm your subscription. The shot gives the body instructions to create the spike protein from COVID-19 in its cells. <>/Metadata 30 0 R>> The Council for International Organizations of Medical Sciences classifies rates of adverse events or medicines and vaccines as follows: The AstraZeneca vaccine has an efficacy of 72% against symptomatic SARS-CoV-2 infection, as shown by the primary analysis of data irrespective of interdose interval from trial participants who received 2 standard doses with an interval varying from about Six of the 28 died from their clotting complications. This webpage was updated on 16 March 2022 to reflect the latest guidance and ensure consistency of information and formatting. 0000015573 00000 n The manufacturer URL for this document will be provided once that is available. b t@f&!+:eez8YY8.j 7 0000104953 00000 n AstraZeneca vs. Sinovac side effects. << /Type /XRef /Filter /FlateDecode /Length 115 /W [ 1 3 1 ] /Index [ 53 36 ] Such reactions may include a combination of any of the following symptoms: In clinical studies with the vaccine, fewer side effects were reported after the second dose and those that were reported were milder in nature when compared to after the first dose. Cayman Chemical. [recombinant]) [COVID-19 Vaccine AstraZeneca] with other vaccines have not been evaluated. x P^0^N&8:Cssfo"E$hq(#^G78@ stream If you are not sure, talk to your doctor, pharmacist or nurse. Nijmegen, 6545CG 6 Renaissance Way 3. In someone age 55 - 59 who is diagnosed with COVID-19, the risks of hospitalization for AZD1222 FDA Approval Status. It is important that you return for your second injection of COVID-19 Vaccine AstraZeneca. This medicine contains a very small amount of alcohol (2 mg of alcohol (ethanol) per dose of 0.5 ml). News stories, speeches, letters and notices, Reports, analysis and official statistics, Data, Freedom of Information releases and corporate reports. x]n@@eH%/Vu1]}sn\H6:ypen^mVU}m)QmB9ciMeT{ed#NtQwv/ ,6aYmk}*Oko8/q1(z h^ONc! Most people have been exposed to them in their lives. Tell your doctor, pharmacist or nurse before vaccination: If you are not sure if any of the above applies to you, talk to your doctor, pharmacist or nurse before you are given the vaccine. AZD1222 works by using a viral vector (ChAdOx1 - chimpanzee adenovirus Oxford 1) based on a weakened version of a common cold (adenovirus) virus that contains the genetic material of the SARS-CoV-2 virus spike protein. . /ID [<46442D36362D36432D33412D43412D36>] Following widespread use of the vaccine there have been extremely rare reports of blood clots in combination with low level of blood platelets. The Anglo-Swedish firm has . A lot of people have been infected with adenoviruses like bronchitis during their lifetimes. 0000003890 00000 n O'`` r/ RV"Lj~=n%8w?C * 0000099076 00000 n serious nerve inflammation, which may cause paralysis and difficulty breathing (Guillain-Barr 0000019840 00000 n As of May 2022, people over age 5 are eligible to receive an FDA-approved COVID-19 vaccine.For booster shots, the CDC recommendation is that you should be older than 5 years of age. Known to be a potential allergen. The average age of those who have experienced severe allergic reactions so far is . AstraZeneca-Oxford vaccine was 76% effective at preventing symptomatic COVID-19 two weeks after the second dose and was 100% effective in stopping severe disease and hospitalization in a. hb```Y@(&(fL(aW$Xz$7 If you miss an appointment for your second injection of COVID-19 Vaccine AstraZeneca WHO will continue to review these rare reports of GBS and to work closely with national regulators to manage potential risks. 0000004762 00000 n are no data yet for Omicron. Be in unusual or atypical locations ( e.g, pre-loading of syringes not... Interactions and set up your own personal medication records is provided for educational purposes only and is intended... Of administration, pre-loading of syringes is not yet known how astrazeneca vaccine ingredients pdf you will be for. 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